TissueBlue (Brilliant Blue G Ophthalmic Solution) 0.025% is a clear, bright blue, single-patient-use ophthalmic solution supplied in 2.25 mL syringes pre‑filled to a volume of 0.5 mL. TissueBlue is indicated to selectively stain the internal limiting membrane (ILM).
Confidence. Consistency. Convenience.
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¹ According to 2025 survey of US retinal Surgeons, ASRS meeting
Confidence of superior purity¹
FDA-approved, pharmaceutical-grade dye.
Consistency & Convenience
Pre-filled, sterile syringe eliminates need to mix or source via compounding pharmacies.
PROVEN SAFETY⁺
Trusted for ILM staining in more than 1 million² procedures worldwide.
⁺Marketed as ILM Blue Outside US since 2010.
References
1. Data on file – Results of HPLC purity tests performed on samples of compounded BBG dyes available in the U.S.
2. Total DORC Global Sales data for ILM Blue since launch – available on file.
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Product Presentation
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Surgical videos
TissueBlue in macular hole repair (video courtesy of Asheesh Tewari, MD (Michigan, USA).
ILM Blue* surgical demonstration
*TissueBlue has been marketed as ILM Blue Outside US since 2010.
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*Sample available to registered US physicians only. Samples subject to availability.
What physicians are saying
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"Upon TissueBlue FDA approval as the only ILM staining agent, I immediately began incorporating it in my surgeries. The clear visualization of TissueBlue allows me to confidently remove ILM in both straightforward and complex membrane peels. As a result, I use TissueBlue in 100% of my macular peel cases. My patients’ outcomes are improved with the use of TissueBlue. Because the surgical objective is more easily achieved, the surgery is thus safer and more predictable. The patient and the surgeon "win" with the incorporation of TissueBlue in retina surgery.
The safety of TissueBlue is the most compelling feature. The surgeon can confidently apply TissueBlue during a case with a low risk of toxicity. Additionally, it is easily removed while only staining the desired ILM layer. I would recommend TissueBlue to both novice and experienced retinal surgeons. In my opinion, visualization is the most important feature of retinal surgery, with the use of TissueBlue visualization is improved and retinal surgery is made easier”
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Downloads
US retina surgeons can stop singing the blues
Highlights of prescribing information
Drug Formulary Pack
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IMPORTANT INFORMATION ABOUT TISSUEBLUE
(Brilliant Blue G Ophthalmic Solution) 0.025%
BRIEF SUMMARY This summary contains important information about TISSUEBLUE (TISH-OO-BLU) Solution. It is not meant to take the place of the full Prescribing Information. Read this information carefully before you prescribe TISSUEBLUE. For full Prescribing Information and Patient Information please see package insert.
WHAT IS TISSUEBLUE? TISSUEBLUE (Brilliant Blue G Ophthalmic Solution) 0.025% is a disclosing agent indicated to selectively stain the internal limiting membrane (ILM). The drug product will be administered by health care professionals only and should never be given to patients to handle.
WHO IS TISSUEBLUE FOR? TISSUEBLUE is indicated to selectively stain the internal limiting membrane (ILM).
WHAT WARNINGS AND PRECAUTIONS SHOULD I BE AWARE OF? Excess TISSUEBLUE should be removed from the eye immediately after staining. When using the syringe, surgeons or staff should make sure the plunger moves smoothly before injecting the solution.
Ask your patient about all the medicines they take, including prescription and over-the-counter medicines, skin products, vitamins and herbal supplements.
WHAT ARE THE POSSIBLE SIDE EFFECTS OF TISSUEBLUE? Adverse reactions that have been reported in procedures that included the use of TISSUEBLUE have often been associated with the surgical procedure. The complications include retinal (retinal break, tear, hemorrhage, and detachment) and cataracts.
WHAT ARE THE INGREDIENTS IN TISSUEBLUE?
Active Ingredient: Brilliant blue G
Inactive Ingredients: Polyethylene glycol and buffered sodium chloride solution (sodium chloride, dibasic sodium phosphate, monobasic sodium phosphate, water for injection).
WHERE SHOULD I GO FOR MORE INFORMATION ABOUT TISSUEBLUE? Go to www.tissueblue.com or call 800-75-DUTCH or 603-778-6929.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.
Dutch Ophthalmic, USA
10 Continental Drive, Bldg 1
Exeter, NH 03833, USA
Website: dorc.eu
Phone: 800-75-DUTCH or 603-778-6929
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